Women taking this drug have more problems with bone fractures. Tamoxifen blocks estrogen in the breast, but it acts like a weak estrogen outside the breast, so it stimulates bone and keeps it from getting thin.
Arimidex, on the other hand, works by preventing the production of estrogen. If a woman has a history of osteoporosis, Arimidex may still be the best choice for her. I think that all women should have a bone density test before they start on Arimidex. I recommend Arimidex to most of my postmenopausal patients who have not yet started either drug. Arimidex offers a small but real improvement over tamoxifen, and in general, side effects are minimal.
A woman who is choosing between Arimidex and tamoxifen should discuss the benefits and risks of each with her physician, including a review of her bone density history.
If a postmenopausal woman has been on tamoxifen for just a couple of months, she could consider switching to Arimidex. Although a recent study suggested there may be some benefit to switching, more research is needed. Talk with your doctor about whether switching from tamoxifen to Arimidex might be right for you. Information from the National Library of Medicine To learn more about this study, you or your doctor may contact the study research staff using the contact information provided by the sponsor.
Please refer to this study by its ClinicalTrials. More Information. Layout table for additonal information ClinicalTrials. Early Breast Cancer. National Library of Medicine U.
National Institutes of Health U. Department of Health and Human Services. The safety and scientific validity of this study is the responsibility of the study sponsor and investigators.
Breast Cancer. Drug: Anastrozole Drug: Tamoxifen. Phase 2. Study Type :. Interventional Clinical Trial. Estimated Enrollment :. Arimidex, also known by its chemical name anastrozole, is an aromatase inhibitor -- a breast cancer drug. While steroids and growth hormone make headlines when athletes abuse them, breast cancer drugs are a lesser-known staple of doping regimens, for athletes and "weekend warriors" alike.
Star therapies of the breast oncology world -- like tamoxifen Nolvadex and exemestane Aromasin -- provide an easy, non-injectable means of cutting estrogen's unwanted side effects.
And bodybuilders are packing other little-known pharmaceuticals into their routines -- some of which, like ghrelin mimetics and selective androgen receptor modulators SARMs , are still under investigation in clinical trials and are not available on any regulated market. Weightlifters don't seem to have a preference for either class of anti-estrogens. There are the selective estrogen receptor modulators SERMs like tamoxifen, or the aromatase inhibitors like anastrozole.
Both classes mitigate the effects of estrogen, which is metabolized from testosterone. When testosterone levels are high, estrogen levels also tend to increase as a natural byproduct. Rowlett's organization champions drug-free bodybuilding, and prescription anti-estrogens are on the group's list of banned substances , modeled on that of the International Olympic Committee. These breast cancer drugs are also on the prohibited performance-enhancing drugs lists from the U. Abuse of breast cancer drugs isn't limited to top athletes.
There are no data on how widely used anti-estrogens are in this community, but Rowlett says it's common practice. Given that they're prescription drugs, the obvious question is how bodybuilders are getting their hands on them. Rowlett says family practice physicians tend to write the scripts directly to those who are working out. There is also the potential for doctor shopping if one clinician refuses, as Thomas pointed out in his video.
And, of course, there's an underground market that anyone with Internet access can peruse.
0コメント