Computational models of the neural control of breathing. Google Scholar. A closed-loop model of the respiratory system: Focus on hypercapnia and active expiration. Rubin, J. Multiple rhythmic states in a model of the respiratory central pattern generator. Toporikova, N.
Two types of independent bursting mechanisms in inspiratory neurons: an integrative model. Journal of Computational Neuroscience 30 , — Abou-Jaoude, W. Logical modeling and dynamical analysis of cellular networks. Albert, R. The topology of the regulatory interactions predicts the expression pattern of the segment polarity genes in drosophila melanogaster. Glass, L. Logical analysis of continuous, nonlinear biochemical control networks.
Kauffman, S. Homeostasis and differentiation in random genetic control networks. Wynn, M. Logic-based models in systems biology: network analysis method. Guyenet, P. Interdependent feedback regulation of breathing by the carotid bodies and the retrotrapezoid nucleus.
Wang, Y. Relations between the dynamics of network systems and their subnetworks. Advances in cellular and integrative control of oxygen homeostasis within the central nervous system.
Abbott, S. Phox2b-expressing neurons of the parafacial region regulate breathing rate, inspiration, and expiration in conscious rats. Abdala, A. Abdominal expiratory activity in the rat brainstem-spinal cord in situ: patterns, origins and implications for respiratory rhythm generation. Koizumi, H. Voltage-dependent rhythmogenic property of respiratory pre-botzinger complex glutamatergic, dbx1-derived, and somatostatin-expressing neuron populations revealed by graded optogenetic inhibition.
Suder, K. One-dimensional, nonlinear determinism characterizes heart rate pattern during paced respiration. Sasano, N. Direct effect of pa co2 on respiratory sinus arrhythmia in conscious humans. Giardino, N. Respiratory sinus arrhythmia is associated with efficiency of pulmonary gas exchange in healthy humans.
Sin, P. Influence of breathing frequency on the pattern of respiratory sinus arrhythmia and blood pressure: old questions revisited. Elstad, M. Respiratory variations in pulmonary and systemic blood flow in healthy humans. Central regulation of heart rate and the appearance of respiratory sinus arrhythmia: New insights from mathematical modeling. Carotid bodies and the integrated cardiorespiratory response to hypoxia. Liss, B.
A role for neuronal k-atp channels in metabolic control of the seizure gate. Devor, A. The great gate: control of sensory information flow to the cerebellum. The Cerebellum 1 , 27—34 Richter, D.
Respiratory rhythm generation in vivo. Tipton, M. The human ventilatory response to stress: rate or depth? Download references.
We would like to acknowledge discussions we had with Julian Paton, Department of Physiology, Auckland University, New Zealand and thank him for commenting on this manuscript. Funding: Y. You can also search for this author in PubMed Google Scholar. Correspondence to Alona Ben-Tal. Reprints and Permissions. The logic behind neural control of breathing pattern. Sci Rep 9, Download citation. Received : 10 January Accepted : 29 May Published : 24 June Anyone you share the following link with will be able to read this content:.
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Biological Cybernetics By submitting a comment you agree to abide by our Terms and Community Guidelines. If you find something abusive or that does not comply with our terms or guidelines please flag it as inappropriate. Advanced search. Skip to main content Thank you for visiting nature. Download PDF. Subjects Applied mathematics Dynamical systems. Abstract The respiratory rhythm generator is spectacular in its ability to support a wide range of activities and adapt to changing environmental conditions, yet its operating mechanisms remain elusive.
Introduction The mechanism for generating and controlling the breathing pattern by the respiratory neural circuit has been debated for some time 1 , 2 , 3 , 4 , 5 , 6. Results Notation and framework setup Figure 1 , panels A and B, show two examples of Boolean networks that can produce bursting in response to a tonic spiking input.
Figure 1. Full size image. Figure 2. Figure 3. Figure 4. Figure 5. Figure 6. Figure 7. Methods Our study is based on logical arguments that we describe below and in the Supplementary Material.
Figure 8. Table 1 Truth table of the network in Fig. Full size table. Table 2 Truth table of the network in Fig. Data Availability All data is available in the main text or the Supplementary Material. References 1. Article Google Scholar 9. Article Google Scholar Google Scholar Acknowledgements We would like to acknowledge discussions we had with Julian Paton, Department of Physiology, Auckland University, New Zealand and thank him for commenting on this manuscript. View author publications.
Ethics declarations Competing Interests The authors declare no competing interests. Supplementary information. Supplementary Materials. About this article. Cite this article Ben-Tal, A. Copy to clipboard. Thomas Biological Cybernetics Comments By submitting a comment you agree to abide by our Terms and Community Guidelines. Publish with us For authors Submit manuscript. Search Search articles by subject, keyword or author.
Populations Of coupled pacemaker neurons. J Neurophysiol — Google Scholar. Cohen MI Neurogenesis of respiratory rhythm in the mammal. Experimental tests of model predictions. Physiol Rev — Google Scholar. Ezure K Synaptic connections between medullary respiratory neurons and considerations on the genesis of the respiratory rhythm.
Feldman JL Neurophysiology of breathing in mammals. In: Handbook of physiology. The nervous system. Am Physiol Soc, Sect. IV, Chap.
Washington, DC, pp — Google Scholar. Academic, Amsterdam Google Scholar. Long S, Duffin J The neuronal determinants of respiratory rhythm. Consider a case in which a person is hyperventilating from an anxiety attack. Their increased ventilation rate will remove too much carbon dioxide from their body. Without that carbon dioxide, there will be less carbonic acid in blood, so the concentration of hydrogen ions decreases and the pH of the blood rises, causing alkalosis.
In response, the chemoreceptors detect this change, and send a signal to the medulla, which signals the respiratory muscles to decrease the ventilation rate so carbon dioxide levels and pH can return to normal levels. There are several other examples in which chemoreceptor feedback applies. A person with severe diarrhea loses a lot of bicarbonate in the intestinal tract, which decreases bicarbonate levels in the plasma.
As bicarbonate levels decrease while hydrogen ion concentrations stays the same, blood pH will decrease as bicarbonate is a buffer and become more acidic. In cases of acidosis, feedback will increase ventilation to remove more carbon dioxide to reduce the hydrogen ion concentration.
Conversely, vomiting removes hydrogen ions from the body as the stomach contents are acidic , which will cause decreased ventilation to correct alkalosis. Chemoreceptor feedback also adjusts for oxygen levels to prevent hypoxia, though only the peripheral chemoreceptors sense oxygen levels.
In cases where oxygen intake is too low, feedback increases ventilation to increase oxygen intake. A more detailed example would be that if a person breathes through a long tube such as a snorkeling mask and has increased amounts of dead space, feedback will increase ventilation.
Respiratory feedback : The chemoreceptors are the sensors for blood pH, the medulla and pons form the integrating center, and the respiratory muscles are the effector. Evaluate the effect of proprioception the sense of the relative position of the body and effort being employed in movement on breathing.
The lungs are a highly elastic organ capable of expanding to a much larger volume during inflation. While the volume of the lungs is proportional to the pressure of the pleural cavity as it expands and contracts during breathing, there is a risk of over-inflation of the lungs if inspiration becomes too deep for too long. Physiological mechanisms exist to prevent over-inflation of the lungs. Cardiac and respiratory branches of the vagus nerve : The vagus nerve is the neural pathway for stretch receptor regulation of breathing.
The Hering—Breuer reflex also called the inflation reflex is triggered to prevent over-inflation of the lungs. There are many stretch receptors in the lungs, particularly within the pleura and the smooth muscles of the bronchi and bronchioles, that activate when the lungs have inflated to their ideal maximum point.
These stretch receptors are mechanoreceptors, which are a type of sensory receptor that specifically detects mechanical pressure, distortion, and stretch, and are found in many parts of the human body, especially the lungs, stomach, and skin. They do not detect fine-touch information like most sensory receptors in the human body, but they do create a feeling of tension or fullness when activated, especially in the lungs or stomach.
When the lungs are inflated to their maximum volume during inspiration, the pulmonary stretch receptors send an action potential signal to the medulla and pons in the brain through the vagus nerve. This is called the inflation reflex. As inspiration stops, expiration begins and the lung begins to deflate. As the lungs deflate the stretch receptors are deactivated and compression receptors called proprioreceptors may be activated so the inhibitory signals stop and inhalation can begin again—this is called the deflation reflex.
Early physiologists believed this reflex played a major role in establishing the rate and depth of breathing in humans. While this may be true for most animals, it is not the case for most adult humans at rest. However, the reflex may determine the breathing rate and depth in newborns and in adult humans when tidal volume is more than 1 L, such as when exercising. Additionally, people with emphysema have an impaired Hering—Bauer reflex due to a loss of pulmonary stretch receptors from the destruction of lung tissue, so their lungs can over-inflate as well as collapse, which contributes to shortness of breath.
As the Hering—Bauer reflex uses the vagus nerve as its neural pathway, it also has a few cardiovascular system effects because the vagus nerve also innervates the heart. During stretch receptor activation, the inhibitory signal that travels through the vagus nerve is also sent to the sinus-atrial node of the heart. Its stimulation causes a short-term increase in resting heart rate, which is called tachycardia.
The heart rate returns to normal during expiration when the stretch receptors are deactivated. When this process is cyclical it is called a sinus arrhythmia, which is a generally normal physiological phenomenon in which there is short-term tachycardia during inspiration.
Sinus arryhthmias do not occur in everyone, and are more common in youth. The sensitivity of the sinus-atrial node to the inflation reflex is lost over time, so sinus arryhthmias are less common in older people.
Privacy Policy. Skip to main content. Respiratory System. Search for:. Respiration Control. Neural Mechanisms Respiratory Center The medulla and the pons are involved in the regulation of the ventilatory pattern of respiration.
Learning Objectives Describe the neural mechanism of the respiratory center in respiration control. Key Takeaways Key Points The ventral respiratory group controls voluntary forced exhalation and acts to increase the force of inspiration.
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